White Wine Raises Melanoma Risk, Study says

(CNN) Alcohol has been linked to several different cancers, some more strongly than others. Now a study adds a new type of cancer to the list, and it's an unexpected one: Brown University researchers say that drinking, even in moderate amounts, is associated with higher rates of melanoma -- the deadliest form of skin cancer.

Their research revealed more interesting facts, as well. In the study, white wine had a bigger impact on melanoma risk than red wine, beer, or liquor. And compared with teetotalers, alcohol drinkers' increased risk was greatest for body parts that normally aren't exposed to the sun.
Some scientists have speculated that alcohol may make us more susceptible to sunburns, says co-author Eunyoung Cho, ScD, an associate professor of dermatology and epidemiology at the Warren Alpert Medical School of Brown University. But the new findings indicate there may be something else going on beneath the surface, she says.
About 3.6% of cancer cases worldwide are thought to be caused by alcohol, the authors note. "For some, like cancers of the digestive tract, the alcohol actually comes in contact with the tissue, so it's easier to understand," says Cho. "For others, like breast cancer, we don't really have a great explanation at this point why alcohol would be related."
One theory, she says, is that a compound in alcohol called acetaldehyde can damage DNA, and prevent DNA repair, throughout the body. "It's a well known carcinogen, so that could be a very general mechanism as to how alcohol relates to cancer at other sites," she says.
There's been little research on alcohol and skin cancer risk, however, and the studies that have been conducted have been inconclusive. They haven't included much information about participants' sun exposure, says Cho, which could affect the results.
So Cho and her colleagues collected data from three large studies involving 210,252 participants, all of whom provided information about their drinking habits, place of residence, and health history -- including details about sunburns and tanning. Over an 18-year follow-up period, 1,374 people (less than 1% of all participants) were diagnosed with invasive melanoma.
The results, published in the journal Cancer Epidemiology, Biomarkers & Prevention, showed that each drink per day was associated with a 14% higher risk of melanoma. (A standard drink was defined as 12.8 grams of pure alcohol, or about the amount found in one beer, glass of wine, or shot of hard liquor.)
And when the researchers looked at each beverage type individually, they found that one drink stood out: Each glass of white wine per day was associated with a 13% increased risk of melanoma, while other forms of alcohol did not affect risk in a statistically meaningful way.
Some research has shown that wine has higher levels of acetaldehyde than beer or spirits, says Cho, while red wine's greater antioxidant content may offset the risks of these compounds.
But she won't let other beverages off the hook just yet. "Other alcoholic beverages did show some positive correlation, but did not reach statistical significance," she says. "For now, I would say that alcohol in general is related, and I would emphasize that white wine is particularly related."
Another surprise came when the researchers looked at melanoma rates on different body parts. People who drank 20 grams or more of alcohol per day (a little less than two drinks) were only 2% more likely than non-drinkers to be diagnosed with melanomas of the head, neck, arms, or legs. But they were 73% more likely to be diagnosed with melanomas of the trunk -- a body part often covered by clothing.
More research is needed to explain why this may be the case, says Cho. "There is a hypothesis that melanomas on different body sites may have different risk factors," she says. "Based on these findings, I might guess that this type of cancer is less related to sun exposure and more related to a biological mechanism of alcohol damaging DNA or preventing DNA repair."
The study only included white people, so the results cannot be generalized to other races or ethnic groups. And because it was observational, it was not able to determine a cause-and-effect relationship between alcohol (and white wine specifically) and melanoma rates.
But the study did control for several factors, including the number of severe sunburns participants had ever had, their number of moles, and the average amount of ultraviolet radiation where they lived. These adjustments help strengthen the theory that alcohol really does play a role in melanoma development, Cho says -- and not simply that people who drink regularly, or who prefer white wine, are more likely to spend hours by the pool or on the beach. (One thing they weren't able to take into account, however, was sun-protection behaviors, such as using sunscreen.)
"There are many risk factors for melanoma that you cannot change, like family history, hair color, and susceptibility to sunburn," Cho says. "But drinking alcohol is something you can change, so it's actually good to know that alcohol is related to melanoma as well as other cancers."
The study's findings support existing recommendations by the American Cancer Society to limit alcohol intake, she notes, but adds that moderate alcohol consumption has also been linked to a lower risk of heart disease. "People already know that alcohol consumption is related to increased risk for many cancers and we are just adding another one to that list," she says. "For those who drink alcohol, its risks and benefits need to be considered individually -- including the risk related to melanoma."
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