Donald Trump hits Marco Rubio on immigration

Washington (CNN) Donald Trump appears to have a new target: Marco Rubio.

The Florida senator has tried to avoid antagonizing the brash Republican front-runner, but on Tuesday evening Rubio finally landed in Trump's crosshairs.

"Senator Marco 'amnesty' Rubio, who has worst voting record in Senate, just hit me on national security - but I said don't go into Iraq. VISION," Trump tweeted.

Trump has a tendency to attack Republicans on the rise -- from GOP presidential rivals Jeb Bush to Carly Fiorina -- and the latest CNN/ORC poll shows an ascendent Rubio on the heels of his widely praised debate performance.

Earlier on Tuesday, Rubio suggested in an interview on Fox News that Trump was not ready to serve as commander-in-chief given Trump's sparse foreign policy knowledge.

But Trump's tweet could indicate that the Florida senator has awoken the elbow-throwing Trump. Rubio has attempted to run an under-the-radar White House campaign that places little emphasis on winning the daily news cycle, and he has expressed exasperation with the media's fascination with Trump's every move. On the whole, however, Rubio has declined to tumble in the mud with Trump.

In return, Trump has largely avoided hitting Rubio on the stump, only chiding him for running against his mentor, former Florida Gov. Jeb Bush.

But the attacks that Trump now seems to have chosen are sharper: Rubio was confronted at CNN's Republican debate about his Senate attendance record, which has suffered since he launched his presidential bid.

It's also no surprise Trump -- who launched his campaign on a cry for tougher immigration policies -- took aim at Rubio on the issue. The Florida senator unsuccessfully lead an attempt to pass a bipartisan comprehensive immigration bill in 2013 that would have provided a path to citizenship for some undocumented immigrants, among other reforms.

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