Using melatonin for sleep is on the rise, study says, despite potential health harms

By Sandee LaMotte, CNN

    (CNN) -- More and more adults are taking over-the-counter melatonin to get to sleep, and some of them may be using it at dangerously high levels, a new study has found.

While overall use among the United States adult population is still "relatively low," the study does "document a significant many-fold increase in melatonin use in the past few years," said sleep specialist Rebecca Robbins, an instructor in the division of sleep medicine for Harvard Medical School, who was not involved in the study.

The study, published Tuesday in the medical journal JAMA, found that by 2018 Americans were taking more than twice the amount of melatonin they took a decade earlier.Experts worry that the pandemic's negative impact on sleep may have further increased the widespread reliance on sleeping aids, Robbins said.

"Taking sleep aids has been linked in prospective studies with the development of dementia and early mortality," she said.

Melatonin has been linked to headache, dizziness, nausea, stomach cramps, drowsiness, confusion or disorientation, irritability and mild anxiety, depression and tremors, as well as abnormally low blood pressure. It can also interact with common medications and trigger allergies.

While short term use for jet lag, shift workers and people who have trouble falling asleep appears to be safe, long-term safety is unknown, according to the National Center for Complementary and Integrative Health at the National Institutes of Health.


Larger dose, little regulation


Since 2006, a small but growing subset of adults are taking amounts of melatonin that far exceed the 5 milligram a day dosage that is typically used as a short term treatment, the study found.

However, pills for sale may contain levels of melatonin that are much higher than what is advertised on the label. Unlike drugs and food, melatonin is not fully regulated by the US Food and Drug Administration, so there are no federal requirements that companies test pills to be sure they contain the amount of advertised melatonin.

"Previous research has found that that melatonin content in these unregulated, commercially available melatonin supplements ranged from - 83% to +478% of the labeled content," said Robbins, who coauthored the book "Sleep for Success! Everything You Must Know About Sleep But are Too Tired to Ask."

Nor are there any requirements that companies test their products for harmful hidden additives in melatonin supplements sold in stores and online. Previous studies also found 26% of the melatonin supplements contained serotonin, "a hormone that can have harmful effects even at relatively low levels," according to the National Center for Complementary and Integrative Health, a department of the National Institutes of Health.

"We cannot be certain of the purity of melatonin that is available over the counter," Robbins said.

Taking too much serotonin by combining medications such as antidepressants, migraine medications and melatonin can lead to a serious drug reaction. Mild symptoms include shivering and diarrhea, while a more severe reaction can lead to muscle rigidity, fever, seizures and even death if not treated.


It's a hormone, not an herb


Because it is purchased over the counter, experts say many people view melatonin as an herbal supplement or vitamin. In reality, melatonin is a hormone made by the pineal gland, located deep within the brain, and released into the bloodstream to regulate the body's sleep cycles.

"There is a view that if it's natural, then it can't hurt," Robbins told CNN in a prior interview on the impact of melatonin on children. "The truth is, we just really don't know the implications of melatonin in the longer term, for adults or kids."

Another reality: Studies have found that while using melatonin can be helpful in inducing sleep if used correctly -- taking it at least two hours before bed -- but the actual benefit is small.

"When adults took melatonin, it decreased the amount of time it took them to fall asleep by four to eight minutes," Dr. Cora Collette Breuner, a professor in the department of pediatrics at Seattle Children's Hospital at the University of Washington, told CNN last March.

"So for someone whotakes hours to fall asleep, probably the better thing for them to do is turn off their screens, or get 20 to 40 minutes of exercise each day, or don't drink any caffeinated products at all," Breuner said.

"These are all sleep hygiene tools that work, but people are very reticent to do them. They rather just take a pill, right?"


Training your brain to sleep


There are other proven sleep tips that work just as well, if not better than sleeping aids, experts say. The body begins secreting melatonin at dark. What do we do in our modern culture? Use artificial light to keep us awake, often long past the body's normal bedtime.

Research has found that the body will slow or stop melatonin production if exposed to light, including the blue light from our smartphones, laptops and the like.

"Any LED spectrum light source may further suppress melatonin levels," said Dr. Vsevolod Polotsky, who directs sleep basic research in the division of pulmonary and critical care medicine at Johns Hopkins University School of Medicine, in a prior CNN interview.

So ban those devices at least an hour before you want to fall asleep. Like to read yourself to sleep? That's fine, experts say, just read in a dim light from a real book or use an e-reader in night mode.

"Digital light will suppress the circadian drive," Polotsky said, while a "dim reading light will not."

Other tips include keeping your bedroom temperature at cooler temperatures of about 60 to 67 degrees Fahrenheit (15 to 20 degrees Celsius). We sleep better if we're a bit chilly, experts say.

Set up a bedtime ritual by taking a warm bath or shower, reading a book or listening to soothing music. Or you can try deep breathing, yoga, meditation or light stretches. Go to bed and get up at the same time each day, even on weekends or your days off, experts say. The body likes routine.

If your doctor does prescribe melatonin to help with jet lag or other minor sleep issues, keep the use "short-term," Robbins said.

If you are planning to use melatonin for a short-term sleep aid, try to purchase pharmaceutical grade melatonin, she advised. To find that, look for a stamp showing the product has been tested by the independent, nonprofit US Pharmacopoeial Convention Dietary Supplement Verification Program.

The-CNN-Wire
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