TORONTO (AP) -- Seattle rookie quarterback Russell Wilson ran for three touchdowns and threw for another in leading the Seahawks to their second straight rout, a 50-17 win over the Bills on Sunday in Buffalo's annual home game in Toronto.

Wilson scored on runs of 14, 25 and 4 yards and then hit Zach Miller for a 4-yard touchdown in helping the Seahawks score 31 points on their first five possessions. The defense then took over by forcing three consecutive turnovers to start the second half, including Earl Thomas scoring on 57-yard interception return.

A week after a 58-0 win at home against Arizona, the Seahawks (9-5) inched closer to clinching a playoff berth and became the NFL's third team to score 50 points on consecutive weekends.

The Bills (5-9) were mathematically knocked out of playoff contention for a 13th consecutive season -- the NFL's longest active drought.